Buserelin Acetate Gonadotropin-Releasing Hormone (GnRH) Agonist
Effective GnRH Analogue for Reproductive and Hormone Therapy
Product Overview
Buserelin Acetate is a synthetic GnRH analogue widely used to treat hormone-dependent diseases such as prostate cancer, endometriosis, and polycystic ovarian syndrome (PCOS). It works by suppressing pituitary secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), reducing downstream sex hormone synthesis.
CAS Number: 68630-75-1
Standard: In-House / IP / EP / BP
Product Details
Buserelin Acetate is extensively used in controlled ovarian hyperstimulation protocols for IVF and other assisted reproductive technologies (ART). By regulating the timing of ovulation, it enhances fertilization, embryo development, and pregnancy outcomes.
Molecular Formula: C62H90N16O15
Molar Mass: 1299.48
Appearance: White or almost-white powder
Solubility: Slightly soluble in DMSO, methanol, and water
Melting Point: 186–188°C
Stability: Hygroscopic
Storage Conditions: Store at 2–8°C; protect from light and moisture
Key Applications
1. Assisted Reproductive Technology (ART)
Buserelin Acetate is essential in regulated ovarian hyperstimulation for IVF. It allows doctors to:
▸ Control follicular development
▸ Prevent early ovulation
▸ Synchronize egg maturation
▸ Enhance fertilization and implantation rates
2. Induction of Ovulation
For women with irregular cycles or ovulatory dysfunction, Buserelin Acetate promotes LH and FSH release, encourages egg maturation and release, improving chances of natural pregnancy or ART success.
3. Male Fertility Treatment
Stimulates gonadotropin production in conditions such as hypogonadotropic hypogonadism, promoting spermatogenesis and improving sperm quality.
4. Treatment for Hormone-Dependent Conditions
Buserelin Acetate is used in:
▸ Prostate Cancer: Reduces testosterone to limit tumor growth
▸ Endometriosis: Lowers estrogen to alleviate pelvic discomfort, inflammation, and menstrual irregularities
▸ PCOS: Controls hormonal imbalances by inhibiting excessive gonadotropin production
Overall Summary
Buserelin Acetate is a highly effective, multipurpose medicinal peptide. It enhances fertility in both men and women, regulates reproductive hormones, and treats hormone-dependent conditions. Its precision and reliability make it an essential tool in modern reproductive endocrinology and advanced fertility treatments.
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