Small Molecular Compounds for Human

A: Avibactam sodium is an organic sodium salt that is the monosodium salt of avibactam. Used in combination with ceftazidime pentahydrate for the treatment of complicated urinary tract infections including pyelonephritis. It has a role as an EC 3.5.

A: The non-β-lactam avibactam (NXL104) with a diaza-bicyclo-octane structure is a β-lactamase inactivator with higher affinity and slower reactivation rates with class A and class C β-lactamases compared to clavulanic acid, sulbactam or tazobactam .

A: Ceftolozane/tazobactam combines a novel cephalosporin with an established β-lactam β-lactamase inhibitor, whereas ceftazidime/avibactam couples a well-known cephalosporin with a novel non-β-lactam β-lactamase inhibitor. Both tazobactam and avibactam target the active site of serine β-lactamases.

A: Masitinib is an antitumor agent used primarily for mast cell tumors, but may have effects on other tumors. Masitinib is a tyrosine kinase inhibitor (TKI) that targets the c-Kit pathway. It is more specific for inhibiting the stem cell factor that regulates mast cell tumor proliferation.

A: Masitinib was administered as an adjunct therapy to standard of care in patients with mild to moderate dementia due to probable AD. After 24 weeks of treatment, masitinib (4.5 mg/kg/day) significantly slowed cognitive deterioration, with acceptable safety.

A: Safety was consistent with masitinib's known profile (diarrhea, nausea, rash, and hematologic events), with no elevated risk of infection. Efficacy results from the independent uptitrated masitinib 6.0 mg/kg/d parallel group were inconclusive, and no new safety signal was observed.