Product Details

CAS Number: 1192491-61-4
Standard: In-House Standard
Appearance: White to Off-White Solid
Storage: Sealed, dry, room temperature

Avibactam Sodium is a non-β-lactam β-lactamase inhibitor of the diazabicyclooctanone (DBO) class. Though it has minimal intrinsic antibacterial activity, it restores the effectiveness of β-lactam antibiotics by inhibiting major β-lactamase enzymes responsible for resistance.

Mechanism of Action

Avibactam acts as a reversible, covalent β-lactamase inhibitor, blocking enzymes that would normally degrade β-lactam antibiotics.

Steps:

• β-lactamase attacks Avibactam's amide bond → ring opening
• Formation of stable enzyme–inhibitor complex → prevents antibiotic degradation
• Stable inhibition without hydrolysis → sustained enzyme suppression
• Slow recovery of enzyme activity → prolonged inhibition

Key Advantages

• Non-β-lactam structure effective against enzymes older inhibitors cannot neutralize
• Strong inhibition of ESBLs, KPC, and AmpC enzymes for multidrug-resistant Gram-negative bacteria
• Used with β-lactam antibiotics (eg, ceftazidime) to restore susceptibility
• Reversible binding allows potent yet controlled inhibition
• Stable and long-lasting enzyme suppression improves treatment outcomes

Applications

• Formulation with β-lactam antibiotics for combination therapy
• Research on antimicrobial resistance (AMR)
• Development of new combination therapies
• Studies of enzyme–inhibitor dynamics
• Medicinal chemistry and structural activity research

Storage & Handling

• Store in sealed, moisture-free conditions
• Keep at room temperature
• Protect from excessive humidity

Conclusion

Avibactam Sodium (CAS 1192491-61-4) is a highly valuable β-lactamase inhibitor with broad-spectrum activity against key resistance mechanisms. Its innovative mechanism, stability, and compatibility with multiple β-lactam antibiotics make it essential in combating multidrug-resistant bacterial infections.