Human Carbetocin (CAS 37025-55-1)
A Long-Acting Synthetic Oxytocin Analogue for Postpartum Hemorrhage Prevention
Product Overview
Human Carbetocin (CAS 37025-55-1) is a long-acting synthetic analogue of oxytocin widely used in obstetrics to prevent and manage postpartum hemorrhage . Known for its increased stability, sustained uterotonic impact, and consistent safety profile, Carbetocin offers an efficient approach for sustaining uterine contraction after childbirth. Its strong clinical performance makes it an essential component in modern maternal healthcare.
Carbetocin is a synthetic long-acting oxytocin eight peptide analog with agonist properties. Compared to naturally produced oxytocin, its clinical and pharmacological properties are mostly similar. While oxytocin is short-acting and rapidly degraded, Carbetocin maintains sustained uterotonic effects with a single dose, making it advantageous for clinical use - especially after cesarean delivery.
CAS Number: 37025-55-1
Quality Standard: In-House Standard
Intended Use: Prevention of uterine atony and treatment of postpartum hemorrhage
Product Details
| Molar Mass | 988.17 |
| Density | 1.218 ± 0.06 g/cm³ (Predicted) |
| Melting Point | 140–160°C |
| Boiling Point | 1477.9 ± 65.0°C (Predicted) |
| Flash Point | 846.7°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Pressure | 0 mmHg at 25°C |
| Appearance | Powder |
| Color | White or almost white |
| pKa | 13.07 ± 0.70 (Predicted) |
| Storage Condition | Stored at 2–8°C, protected from light and moisture |
Applications
1. Uterotonic Action and Receptor Binding
Like oxytocin, Carbetocin binds to hormone-producing receptors in the uterine smooth muscle, triggering rhythmic contractions of the uterus. Building on the uterus's natural contractions, Carbetocin increases both their frequency and overall uterine tension.
▸ In a non-pregnant state, the uterus has a very low concentration of oxytocin receptors
▸ Receptors gradually increase during pregnancy, reaching their peak at the time of delivery
▸ Carbetocin has no effect on the non-pregnant uterus but effectively induces contractions in the pregnant uterus and postpartum period
2. Prevention of Postpartum Hemorrhage (PPH)
Carbetocin is primarily used following cesarean sections under selective epidural or spinal anesthesia to prevent uterine atony and reduce the risk of postpartum hemorrhage. Compared with natural oxytocin, Carbetocin has:
▸ Significantly longer duration of action
▸ Stronger stability and improved receptor affinity
▸ Sustained uterotonic effects with a single dose
Why Choose Our Product
▸ Manufactured under strict GMP-compliant production standards
▸ High purity with consistent peptide quality
▸ Stable supply capacity for global pharmaceutical manufacturers
▸ Full technical documentation available (DMF, COA, specifications, impurities profile)
Conclusion
Human Carbetocin Pharmaceutical Grade (CAS 37025-55-1) is an essential API in modern obstetric care. Its sustained uterotonic action, superior stability over natural oxytocin, and proven efficacy in preventing postpartum hemorrhage make it the preferred choice for cesarean protocols delivery worldwide. Manufactured under rigorous GMP-compliant conditions with full documentation support, it meets the highest standards required by pharmaceutical formulators and maternal healthcare providers globally.
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