Avibactam Sodium
Potent Non-β-Lactam β-Lactamase Inhibitor for Multidrug-Resistant Infections
Product Overview
Avibactam Sodium is a novel β-lactamase inhibitor used in combination with β-lactam antibiotics to combat infections caused by multidrug-resistant bacteria. By inhibiting β-lactamase enzymes responsible for antibiotic resistance, it restores the antibacterial activity of partner drugs and improves therapeutic outcomes in serious infections.
CAS Number: 1192491-61-4
Standard: In-House / IP / EP / BP Standard
Key Applications
1. Complicated Urinary Tract Infections (cUTIs)
Demonstrates strong efficacy against multidrug-resistant gram-negative bacteria, including resistant strains of Escherichia coli and Klebsiella pneumoniae .
2. Hospital-Acquired Infections
Used in the treatment of hospital-acquired and ventilator-associated pneumonia caused by resistant pathogens such as Pseudomonas aeruginosa and Acinetobacter baumannii .
3. Complicated Intra-Abdominal Infections (cIAIs)
Enhances the effectiveness of cephalosporins in treating polymicrobial and resistant intra-abdominal infections.
4. Multidrug-Resistant Gram-Negative Pathogens
Plays a critical role in overcoming β-lactamase-mediated resistance mechanisms and restoring the efficacy of last-line antibiotics.
Safety & Tolerability
Avibactam Sodium is generally well tolerated and exhibits a favorable safety profile when used in approved combination therapies. Its balance of efficacy and tolerability makes it a valuable option in the management of severe resistant infections.
Conclusion
Avibactam Sodium represents a significant advancement in antimicrobial therapy. By restoring antibiotic effectiveness against resistant bacteria, it supports improved clinical outcomes and addresses the growing global challenge of antimicrobial resistance.
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