Product Details

CAS Number: 123456-78-9
Class: Isoxazoline
Appearance: Off-White to Pale Beige Solid
Dosage Form: Oral chewable tablets
Duration of Action: 30–35 days per dose
Storage: Refrigerated, sealed

Sarolaner is a next-generation isoxazoline ectoparasiticide, highly effective against fleas, ticks, and some mites in dogs and cats. It offers rapid and long-lasting protection via oral administration.

Mechanism of Action

Sarolaner works by inhibiting GABA- and glutamate-gated chloride channels in the nervous system of insects and acarines, resulting in paralysis and death of the parasites.

Steps:

• Inhibition of chloride channels → disruption of neural transmission
• Parasite paralysis → inability to feed or move
• Rapid death of fleas and ticks within hours
• Protection maintained for up to 35 days

Key Advantages

• Fast-acting: kills fleas in 3–4 hours, ticks in 8 hours
• Long-lasting: one oral dose provides up to 35 days of protection
• Well-tolerated: good safety profile at recommended doses
• Supports prevention of tick-borne diseases by killing ticks before transmission

Veterinary Applications

• Flea and tick prevention and treatment in dogs and cats
• Part of monthly parasite control protocols
• Reduces risk of tick-borne disease transmission (eg, Lyme disease)
• Combination therapy with other parasiticides or veterinary treatments as needed

Storage & Handling

• Store in a sealed, dry container
• Keep refrigerated
• Protect from moisture and direct sunlight

Conclusion

Sarolaner is a highly effective, fast-acting, and long-lasting oral ectoparasiticide for dogs and cats. Its broad activity against fleas, ticks, and certain mites, combined with a strong safety profile, makes it an essential component of modern veterinary parasite control programs.