Maropitant Citrate (CAS 147116-67-4)
A High-Purity NK-1 Receptor Antagonist for Veterinary Anti-Vomiting Therapy
Maropitant Citrate , identified by CAS Number 147116-67-4 , is a trusted active pharmaceutical ingredient (API) widely used in veterinary medicine to prevent and treat nausea and vomiting in dogs and cats. Manufactured according to in-house quality standards , this compound delivers reliable purity, stability, and efficacy for use in veterinary formulations.
As a neurokinin-1 (NK-1) receptor antagonist , Maropitant Citrate plays a crucial role in blocking vomiting pathways in the central nervous system. It is the active ingredient in several anti-emetic medications, including the widely known veterinary brand Cerenia .
Chemical Information & Product Specifications
CAS Number: 147116-67-4
Molecular Formula: C₃₂H₄₀N₂O
Molar Mass: 468.67 g/mol
Density (Predicted): 1.11 ± 0.1 g/cm³
Boiling Point (Predicted): 572.6 ± 50.0 °C
Vapor Pressure: 0–0 Pa at 20–25 °C
pKa (Predicted): 9.99 ± 0.70
Appearance: White to pale yellow powder
Solubility: Dissolves readily in water and ethanol
Storage Condition: 2–8 °C
These chemical and physical characteristics support its stable performance in both injectable and oral dosage forms.
What is Maropitant Citrate?
Maropitant Citrate is a high-efficacy anti-emetic API formulated to suppress vomiting and nausea in companion animals. Its mechanism of action centers on blocking the binding of substance P -a neurotransmitter responsible for activating the vomiting reflex-to NK-1 receptors located in:
▸ The brainstem (chemoreceptor trigger zone)
▸ The gastrointestinal tract
▸ Other areas of the central nervous system
By inhibiting this pathway, the compound effectively prevents vomiting triggered by various causes.
Key Veterinary Applications
▸ Prevention and Treatment of Vomiting
▸ Motion Sickness in Dogs
▸ Chemotherapy-Induced Vomiting
▸ Gastrointestinal Disorders
Benefits and Advantages
▸ Highly Effective Anti-Emetic
▸ Well-Tolerated by Most Pets
▸ Suitable for Multiple Dosage Forms (Tablets, Oral solutions, Injectable preparations)
▸ Fast Onset and Long-Lasting Effect
Storage and Handling
For optimal quality, Maropitant Citrate should be stored at 2–8 °C , protected from light and moisture, and handled in accordance with standard pharmaceutical safety guidelines.
Conclusion
Maropitant Citrate (CAS 147116-67-4) is a highly effective and dependable API for preventing and managing nausea and vomiting in dogs and cats. Its mechanism as a selective NK-1 receptor antagonist enables broad anti-emetic activity, covering motion sickness, chemotherapy reactions, and gastrointestinal disturbances. With strong solubility, excellent safety, and proven therapeutic performance, Maropitant Citrate remains an essential ingredient in modern veterinary medicine.
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