Trilostane (CAS 13647-35-3) – Veterinary API for Cushing's Syndrome
Basic Information
▸ Standard: In-house standard
▸ Category: Veterinary Active Pharmaceutical Ingredient (API)
Applications of Trilostane
1. Treatment for Canine Cushing's Syndrome
Used as first-line treatment for:
- Pituitary-dependent Hyperadrenocorticism (PDH)
- Adrenal-dependent Hyperadrenocorticism (ADH)
Helps alleviate symptoms such as excessive thirst/urination, increased appetite, hair loss, skin issues, abdominal enlargement, and muscle weakness.
2. Treatment of Functional Adrenal Tumours
Regulates hormone overproduction caused by adrenal neoplasia, providing symptom relief for pets not suitable for surgery.
3. Off-Label Use for Other Species
May be used by veterinarians for:
- Feline hyperadrenocorticism
- Certain equine endocrine disorders
Usage outside canine medicine requires professional judgment and ongoing research.
Mechanism of Action
Trilostane inhibits 3β-hydroxysteroid dehydrogenase in adrenal steroidogenesis, resulting in:
- Reduced cortisol production
- Reduced aldosterone synthesis
- Improved clinical symptoms of glucocorticoid excess
Monitoring and Safety
Regular monitoring is critical due to its effect on adrenal hormones:
- ACTH stimulation testing
- Serum cortisol levels
- Electrolyte profiles
- Clinical assessment (energy, appetite, hydration, coat condition)
Possible adverse effects include lethargy, vomiting/diarrhea, electrolyte imbalance, and rare iatrogenic hypoadrenocorticism. Prompt veterinary supervision ensures safety and effectiveness.
Why Choose Our Trilostane
- High-quality API manufacturing: Produced under strict in-house standards with rigorous QC.
- Consistency and purity: Each batch checked for identity, purity, potency, and stability.
- Compliance and reliability: Manufactured in accordance with GMP and ICH Q7 guidelines.
Packaging and Delivery
- Express Delivery: DHL, FedEx
- Air Freight: Fast, secure transportation for bulk orders
All shipments are carefully packaged to ensure product integrity.
Global Market Presence
- Europe
- Asia
- South America
- North America
Leading veterinary pharmaceutical manufacturers rely on this API for purity, stability, and consistency.
FAQs
Q1: What conditions does Trilostane treat?
A: Primarily canine Cushing's syndrome; may also be used for adrenal tumors and off-label endocrine conditions in other species.
Q2: Can I visit your facility?
A: Yes, factory tours and quality audits are available by appointment.
Q3: Are pricing and stock competitive?
A: Yes, direct-from-factory products ensure low prices and most APIs are in stock for immediate dispatch.
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