Denaverine Hydrochloride – Smooth Muscle Relaxant
Basic Information
▸ CAS Number: 3321-06-0
▸ Standard: In-house standard
Applications
1. Smooth Muscle Relaxant
Denaverine HCl reduces spasms in smooth muscles of the digestive, reproductive, and circulatory systems, providing relief in painful contractions.
2. Uterine Relaxant (Obstetric Use)
Relaxes uterine muscles during labor, beneficial for:
- Uterine hypertonicity (excessive contraction)
- Delayed cervical dilatation
- Difficult or blocked labor
3. Treatment of Dystocia
Denaverine HCl supports prolonged or painful labor by:
- Relaxing the uterus
- Improving labor progression
- Reducing stress for mother and fetus
4. Treatment for Smooth Muscle Spasms
Relieves spasms in:
- Gastrointestinal diseases (IBS, colic)
- Urological issues (ureteral colic, bladder spasms)
5. Vasodilation
Relaxes blood vessel walls, useful in:
- Peripheral vascular diseases
- Hypertension
- Conditions requiring improved circulation
6. Phosphodiesterase Inhibitory Activity
Acts as a phosphodiesterase inhibitor, raising cAMP in smooth muscles, enhancing relaxation and blood flow.
7. Labour Induction Support
May assist in inducing or accelerating labor by controlled uterine relaxation and promoting cervical dilation.
Side Effects
▸ Dizziness
▸ Nausea or vomiting
▸ Headache
▸ Facial flushing
Most side effects are mild and resolve quickly; monitoring is recommended during administration.
Dosage
Dosage depends on the condition, patient health, and administration route. Common routes include:
- Intravenous (IV)
- Intramuscular (IM)
Should always be administered under competent medical supervision.
Contraindications
Not recommended for individuals with:
- Known hypersensitivity to Denaverine or its components
- Severe cardiovascular disorders
- First trimester pregnancy
Healthcare providers should review patient history carefully before administration.
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