Ulinastatin for Human Use - Powerful Anti-Inflammatory & Organ-Protective Therapy
Product Details
▸ CAS Number: 80449-31-6
▸ Standard: In-House / IP / EP / BP Standard
Ulinastatin is a highly effective protease inhibitor derived from human urine, widely used in modern medicine for its potent anti-inflammatory, tissue-protective, and organ-stabilizing properties. In a variety of clinical contexts, it is essential for treating acute inflammatory conditions, promoting healing, and averting serious tissue damage.
Ustatin (Ulinastatin) is a naturally occurring glycoprotein purified from the urine of healthy adult males. With 143 amino acids in its composition, it works as a strong protease inhibitor, capable of inhibiting various damaging enzymes responsible for inflammation and tissue death.
Its inhibiting action targets important enzymes such as:
▸ Trypsin from the pancreas
▸ α-Serine proteases (including chymotrypsin)
▸ Neutrophil elastase
▸ Hyaluronidase
▸ Thiolase
▸ Plasmin
By suppressing these enzymes, Ulinastatin helps control the inflammatory response and protects multiple organ systems.
Applications of Ulinastatin
Ulinastatin is widely recognized for its broad therapeutic benefits and is frequently used to manage severe inflammation, protect tissues from damage, and support faster recovery in critical illnesses.
1.Acute Pancreatitis Treatment
One of the most established medical uses of Ulinastatin is in acute pancreatitis.
Its benefits include:
▸ Inhibiting inflammatory proteases
▸ Reducing pancreatic autodigestion
▸ Preventing systemic inflammation
Minimizing tissue injury
▸ Lowering the risk of complications
This makes Ulinastatin a core therapeutic option in managing moderate to severe pancreatitis.
2. Sepsis & SIRS (Systemic Inflammatory Response Syndrome)
In severe systemic inflammatory states such as sepsis and SIRS, uncontrolled enzyme activity can lead to widespread organ failure.
Ulinastatin helps by:
▸ Modulating the inflammatory cascade
▸ Controlling excessive protease activity
▸ Reducing oxidative stress
▸ Protecting vital organs (lungs, kidneys, liver)
▸ Supporting improved survival and recovery
Its dual anti-inflammatory and immunomodulatory actions make it an important supportive therapy in critical care.
3. Perioperative & Postoperative Care
Ulinastatin is increasingly used in surgical practice, especially in:
▸ Major abdominal surgery
Cardiac surgery
▸ Neurosurgery
Benefits include:
▸ Reduced perioperative inflammation
▸ Lower risk of postoperative complications
▸ Improved clinical stability
▸ Faster healing
▸ Shorter hospital stays
This makes it a valuable addition to enhanced recovery protocols.
4. Neurological Protection (TBI & Stroke)
Emerging research highlights the potential of Ulinastatin in treating conditions involving acute neurological injury, including:
▸ Traumatic brain injury (TBI)
▸ Ischemic stroke
▸ Intracranial hemorrhage
By reducing neuroinflammation and oxidative damage, Ulinastatin may help preserve neuronal function and improve neurological outcomes.
Why Ulinastatin Is Valuable in Modern Medicine
▸ Controls harmful enzymes
▸ Reduces inflammation at the source
▸ Protects multiple organs from damage
▸ Supports faster and smoother recovery
▸ Enhances patient outcomes in critical care and surgery
Its versatile clinical applications continue to expand as new studies reinforce its value across various medical fields.
Hot Tags: ulinastatin for human use, China ulinastatin for human use manufacturers, suppliers, factory, api integrations with content management systems, protein packaging, protein isolation, therapeutic proteins, api data storage, api training
