Trilostane
A Trusted Endocrine-Modulating Agent for Veterinary Medicine
Product Overview
Trilostane is a reliable endocrine-modulating pharmaceutical widely used in veterinary medicine, particularly for the treatment of Cushing's syndrome (hyperadrenocorticism) in dogs. Trilostane works by blocking 3β-hydroxysteroid dehydrogenase, a crucial enzyme in cortisol synthesis, to reduce excess cortisol levels and restore hormonal balance.
It is also used to treat disorders such as Alopecia X, hyperadrenocorticism in cats and horses, and has further scientific applications in endocrine studies.
Product Name: Trilostane API
Molecular Formula: C20H27NO3
Drug Class: Endocrine-Metabolic Agent
Appearance: White to almost white powder
Product Details
| Molecular Formula | C20H27NO3 |
| Drug Class | Endocrine-Metabolic Agent |
| Density | 1.1213 (rough estimate) |
| Melting Point | 264 °C |
| Boiling Point | 467.02°C (rough estimate) |
| Flash Point | 254.8°C |
| Solubility | DMSO: ≥17mg/mL |
| Vapor Pressure | 5.39E-12 mmHg at 25°C |
| pKa | 8.57 ± 0.70 (Predicted) |
| Appearance | Powder form |
| Color | White to almost white |
| Storage Condition | Store at room temperature, away from moisture and heat. Keep in a tightly closed container. |
Mechanism of Action
Trilostane inhibits 3β-hydroxysteroid dehydrogenase, an enzyme responsible for producing cortisol, aldosterone, and other adrenal hormones. By blocking this pathway, it efficiently lowers high steroid hormone levels, making it a standard treatment for endocrine problems in veterinary practice.
▸ Blocks adrenal cortisol and aldosterone synthesis
▸ Restores hormonal balance in hyperadrenocorticism
▸ Reduces clinical symptoms associated with excess cortisol
▸ Supports endocrine regulation across multiple species
Applications
1. Treating Cushing's Syndrome in Dogs
Trilostane is the primary treatment for both pituitary-dependent and adrenal-dependent hyperadrenocorticism. It aids in managing common symptoms such as:
▸ Extreme thirst and urination
▸ Increased appetite
▸ Hair loss and coat thinning
▸ Muscular weakness and lethargy
Quality of life is considerably improved by managing cortisol production.
2. Treatment for Hyperaldosteronism
In dogs with primary hyperaldosteronism, trilostane lowers aldosterone secretion, which helps stabilize:
▸ Blood pressure
▸ Electrolyte imbalances (potassium and sodium levels)
3. Dermatological Conditions (Alopecia X)
Off-label Trilostane use benefits some dog breeds by improving hair regeneration and hormonal balance associated with Alopecia X, offering a non-invasive therapeutic option for affected animals.
4. Endocrine Diseases in Cats and Horses
Trilostane is also used under veterinary supervision to treat hormonal abnormalities in cats and horses. While dosing protocols differ from canine applications, it provides effective endocrine regulation across species.
5. Potential Application in Postmenopausal Breast Cancer
Trilostane has been investigated in human medicine for the treatment of recurrent breast cancer in postmenopausal women due to its ability to disrupt steroid production pathways, demonstrating broader pharmaceutical relevance beyond veterinary use.
Packaging & Delivery
We provide flexible shipping options tailored to your region and timeline:
▸ Express: DHL and FedEx
▸ Air Freight: Global delivery available
▸ Secure Packaging: Moisture-proof, sealed containers to keep products stable
Sales & Services
Henan Medscience is committed to building long-term partnerships both domestically and internationally. We continuously export to Europe, North America, South America, the Middle East, and Asia. Our clients consistently praise our reliable quality, technical support, and professional service.
Why Choose Us?
Competitive Factory Pricing
All products are manufactured in-house, ensuring cost-effective and consistent supply directly from the source.
Custom Solutions
We welcome inquiries that include:
▸ Required specifications
▸ Order quantity
▸ Preferred delivery terms
▸ Expected purchase timeline
Our team will provide tailored quotations and technical guidance.
Products in Stock
Most goods, including Trilostane, are ready for immediate distribution. Please contact us at any time to ensure prompt processing and delivery.
Conclusion
Trilostane Pharmaceutical Grade is a highly effective endocrine-modulating agent with proven applications in treating Cushing's syndrome, hyperaldosteronism, and other hormonal disorders in dogs, cats, and horses. Its well-established safety profile and broad therapeutic utility make it a cornerstone product in modern veterinary endocrinology. When used responsibly under professional supervision, Trilostane delivers reliable and lasting benefits for animal health and quality of life.
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