API Maropitant Citrate
A Widely Used Veterinary Anti-Emetic Ingredient for Dogs and Cats
Maropitant Citrate is a widely used veterinary active pharmaceutical ingredient (API) designed to prevent and control nausea and vomiting in companion animals, particularly dogs and cats. Known for its targeted mechanism of action and strong safety profile, Maropitant Citrate has become a cornerstone ingredient in modern veterinary antiemetic therapies.
▸ Product Name: Maropitant Citrate
▸ CAS Number: 147116-67-4
▸ Standard: In-house standard
▸ Category: Neurokinin-1 (NK1) receptor antagonist
▸ Intended Use: Veterinary pharmaceutical formulations
Maropitant Citrate provides veterinarians with a reliable solution for nausea and vomiting control, supporting animal comfort and treatment compliance.
Mechanism of Action
Maropitant Citrate works by selectively blocking neurokinin-1 (NK1) receptors, which are activated by substance P-a neuropeptide responsible for triggering nausea and vomiting in both the central nervous system and the gastrointestinal tract. By inhibiting this pathway, Maropitant Citrate effectively suppresses the vomiting reflex regardless of the underlying cause.
This targeted mechanism allows for strong antiemetic efficacy without affecting consciousness or causing sedation.
Product Specifications
▸ Molecular Formula: C₃₂H₄₀N₂O
▸ Molar Mass: 468.67 g/mol
▸ Density: 1.11 ± 0.1 g/cm³ (predicted)
▸ Boiling Point: 572.6 ± 50.0 °C (predicted)
▸ Vapor Pressure: 0–0 Pa at 20–25°C
▸ pKa: 9.99 ± 0.70 (predicted)
▸ Appearance: Powder
▸ Color: White to pale yellow
▸ Storage Conditions: 2–8°C
Applications in Veterinary Medicine
Maropitant Citrate is primarily used to prevent and treat vomiting and nausea in dogs and cats. Its long duration of action allows a single dose to provide effective relief for up to 24 hours, significantly improving treatment compliance and convenience.
Key Veterinary Uses
▸ Prevention and treatment of acute and chronic vomiting
▸ Management of motion sickness during travel
▸ Control of nausea associated with anxiety or stress
▸ Supportive treatment in conditions such as pancreatitis
▸ Management of vestibular disorders
The API is suitable for formulation into various dosage forms, including tablets, injectable solutions, and transdermal preparations, offering flexibility for different clinical and commercial needs.
Advantages of Maropitant Citrate API
▸ Long-lasting antiemetic effect (up to 24 hours)
▸ Non-sedating and does not affect mental alertness
▸ Well-tolerated with a strong safety profile
▸ Minimal risk of drug interactions
▸Suitable for combination therapy
Safety and Tolerability
Maropitant Citrate is generally well tolerated when used according to veterinary guidelines. It can be safely administered alongside other medications without significant adverse interactions, making it a reliable option in both routine and complex treatment protocols.
Manufacturing & Supply Capabilities
▸ Production: Manufactured in company-owned facilities
▸ Customization: Flexible packaging and transportation options available upon request
▸ Logistics: Packaging and shipping methods can be adjusted to meet customer needs (additional costs may apply)
Summary
API Maropitant Citrate is a high-quality veterinary pharmaceutical ingredient trusted for its effectiveness in controlling nausea and vomiting in companion animals. Its targeted NK1 receptor antagonism, long duration of action, and non-sedating nature make it an essential component in modern veterinary antiemetic formulations. Pharmaceutical manufacturers and veterinarians alike rely on Maropitant Citrate to improve animal comfort, treatment outcomes, and overall quality of care.
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