Ulinastatin (Ustatin)
A Potent Anti-Inflammatory Glycoprotein for Critical Care, Oncology, and Cosmetics
Ulinastatin, commonly known as Ustatin, is a natural glycoprotein derived and purified from the urine of healthy adult males. Ulinastatin is widely recognized for its potent anti-inflammatory, anti-protease, and immunomodulatory properties, and it is employed in a variety of clinical settings, including critical care, oncology, and cosmetics.
Product Details
Ulinastatin, a 143-amino-acid glycoprotein, acts as a broad-spectrum protease inhibitor. It significantly inhibits pancreatic trypsin, α-serine proteases, chymotrypsin, and other enzymes that cause inflammation and tissue damage. It also inhibits:
▸ Neutrophil elastase
▸ Hyaluronidase
▸ Plasmin
▸ Thiolase
These inhibitory qualities are critical to its therapeutic efficacy in decreasing inflammation and preventing organ damage.
Applications
Ulinastatin is a versatile and clinically useful agent with a wide range of applications:
1.Acute Pancreatitis Treatment
Ulinastatin is commonly used as a first-line treatment for acute pancreatitis, when severe inflammation can cause systemic problems. It greatly lowers inflammatory cytokine levels, thereby stabilizing the patient and improving recovery prospects.
2. Sepsis and Severe Infection
Ulinastatin helps decrease overwhelming inflammatory reactions in sepsis, which can lead to multiple organ failure. Its immunomodulatory impact raises survival rates and lowers complications in severely ill patients.
3. Surgical Protection and Post-Operative Recovery
Ulinastatin is commonly used in large abdominal or thoracic surgery to:
▸ Reduce post-operative inflammation
▸ Reduce risk of complications
▸ Improve organ protection
Its ability to stabilize enzyme activity makes it useful during perioperative treatment.
4. Oncology Support
Ulinastatin is used as an additional medication to treat cancer:
▸ Reduces chemotherapy-related nausea and vomiting
▸ Maintains immunological equilibrium during treatment
▸ Potentially slows tumor development (as shown in emerging research)
This makes it an important collaborator in multi-modal cancer treatment.
5. Anti-Aging and Cosmetic Applications
Ulinastatin is increasingly being employed in cosmetic products due to its strong antioxidant and anti-inflammatory effects:
▸ Reduces oxidative stress
▸ Prevents collagen degradation
▸ Slows formation of wrinkles and fine lines
Its antioxidant properties promote healthier, more youthful-looking skin.
Summary
Ulinastatin is a highly flexible medicinal agent that has demonstrated benefits in:
▸ Critical care for sepsis and pancreatitis
▸ Surgical assistance and postoperative recovery
▸ Oncology support
▸ Cosmetic and anti-aging uses
Its extensive anti-protease, anti-inflammatory, and immunoregulatory properties make it a useful tool in both clinical and research settings.
Our Strengths
✔ Fully GMP-Compliant Manufacturing System
▸ Facility size: 2,523 m²
▸ 365 m² clean area (Class D)
▸ Complete conformity with GMP requirements
✔ Tight Quality Control
Every batch is closely monitored from raw materials to finished product, assuring consistent purity and performance.
✔ Excellent Customer Service
We focus on customer happiness by providing dedicated support, technical guidance, and flexible service alternatives.
Frequently Asked Questions (FAQs)
Q1: What industries are your products suitable for?
Our products are widely used in reproduction, endocrinology, gynecology, cancer, and critical care, servicing both human and veterinary needs.
Q2: Can we come to your factory for a quality audit?
Yes, we welcome customers to conduct on-site audits. Please contact us to schedule your visit - we are always ready to assist you.
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